The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers

Table 3 Summary of QTcF-prolongation by treatment group

Variable	Group 1	Group 2	Group 3 and 4
ECG measurements	12	12	24
QT prolongation events	0	0	0
Grade 1 (mild)	0	0	0
Grade 2 (moderate)	0	0	0
Grade 3 (severe)	0	0	0
Maximum △QTcF (ms)	7.7 (5.8, 15)	14.1 (11.5, 20.2)	7.3 (− 7.6, 34)
Events with DQTcF > 30 ms < 60 ms	0	0	1
Events with DQTcF ≥ 60 ms	0	0	0
Maximum QTcF (ms)	383.9 (379.5, 403.6)	403.5 (400.7, 427.9)	413.1 (388.5, 420.1)
Time after dose at maximum QTcF (days)	7.9 (4.2, 27.9)	7.7 (7.7, 26.9)	28.9 (4.4, 29.1)

Group 1: volunteers received 400 mg of Maytenus senegalensis once; Group 2: volunteers received 600 mg of M. senegalensis once; Group 3 & 4: volunteers received 800 mg of M. senegalensis every 8 h for 4 days; QTcF: QT interval corrected by Fridericia formula; DQTcF: change in QTcF from baseline; mild QT prolongation: QTcF interval > 450 to ≤ 480 ms; moderate QT prolongation: QTcF interval > 480 to ≤ 500 ms; severe QT prolongation: QTcF interval > 500 ms. Values are reported as n or median (2.5th, 97.5th) percentile range

ISSN: 1475-2875