Table 2 ¹ H, ¹³ C NMR data of related impurity (2 and 12) of piperaquine phosphate

1

-

-

-

-

2

7.95 (1H, d, 7.4)

139.9

8.45 (2H, d, 7.1)

144.5

3

6.10 (1H, d, 7.4)

109.2

7.09 (2H, d, 7.2)

107.2

4

11.91 (1H, s)

176.2

-

164.2

5

8.11 (1H, d, 8.7)

127.2

8.33 (2H, d, 9.3)

131.4

6

7.33 (1H, d, 10)

123.4

7.71 (2H, d, 7.8)

131.0

7

-

136.2

-

121.7

8

7.63 (1H, s)

117.4

8.07 (2H, d, 1.7)

122.8

9

-

140.8

-

143.4

10

-

124.3

-

120.4

11

-

-

-

-

12

-

-

4.48 (8H, s)

52.9