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  1. Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to nega...

    Authors: Maria S Herbas, Yoshiko Y Ueta, Chie Ichikawa, Mayumi Chiba, Kana Ishibashi, Mototada Shichiri, Shinya Fukumoto, Naoaki Yokoyama, Motohiro Takeya, Xuenan Xuan, Hiroyuki Arai and Hiroshi Suzuki
    Citation: Malaria Journal 2010 9:101
    Content type: Research Published on:

  2. Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-...

    Authors: Lars M Joergensen, Ali Salanti, Tina Dobrilovic, Lea Barfod, Tue Hassenkam, Thor G Theander, Lars Hviid and David E Arnot
    Citation: Malaria Journal 2010 9:100
    Content type: Research Published on:

  3. School children have been increasingly recognized as health messengers for malaria control. However, little evidence is available. The objective of this study was to determine the impact of school-based malari...

    Authors: Irene Ayi, Daisuke Nonaka, Josiah K Adjovu, Shigeki Hanafusa, Masamine Jimba, Kwabena M Bosompem, Tetsuya Mizoue, Tsutomu Takeuchi, Daniel A Boakye and Jun Kobayashi
    Citation: Malaria Journal 2010 9:98
    Content type: Research Published on:

  4. Both artemether and artesunate have been shown to be superior to quinine for the treatment of severe falciparum malaria in Southeast Asian adults, although the magnitude of the superiority has been greater for...

    Authors: Nguyen H Phu, Phung Q Tuan, Nicholas Day, Nguyen TH Mai, Tran TH Chau, Ly V Chuong, Dinh X Sinh, Nicholas J White, Jeremy Farrar and Tran T Hien
    Citation: Malaria Journal 2010 9:97
    Content type: Research Published on:

  5. Effective malaria control depends on timely acquisition of information on new cases, their location and their frequency so as to deploy supplies, plan interventions or focus attention on specific locations app...

    Authors: Aniset Kamanga, Petros Moono, Gillian Stresman, Sungano Mharakurwa and Clive Shiff
    Citation: Malaria Journal 2010 9:96
    Content type: Methodology Published on:

  6. Rapid diagnostic tests (RDTs) for malaria are at the early stages of introduction across malaria endemic countries. This is central to efforts to decrease malaria overdiagnosis and the consequent overuse of va...

    Authors: Clare IR Chandler, Christopher JM Whitty and Evelyn K Ansah
    Citation: Malaria Journal 2010 9:95
    Content type: Research Published on:

  7. Apical membrane antigen 1 (AMA-1) and merozoite surface protein 1 (MSP1) of Plasmodium falciparum are two leading blood-stage malaria vaccine candidates. A P. falciparum chimeric protein 2.9 (PfCP-2.9) has been c...

    Authors: Changling Li, Rui Wang, Yuan Wu, Dongmei Zhang, Zhicheng He and Weiqing Pan
    Citation: Malaria Journal 2010 9:94
    Content type: Research Published on:

  8. In the 1990s, the experience of eliminating malaria from Aneityum Island, Vanuatu is often given as evidence for the potential to eliminate malaria in the south-west Pacific. This experience, however, cannot p...

    Authors: Jo-An M Atkinson, Lisa Fitzgerald, Hilson Toaliu, George Taleo, Anna Tynan, Maxine Whittaker, Ian Riley and Andrew Vallely
    Citation: Malaria Journal 2010 9:93
    Content type: Research Published on:

  10. Agricultural practices such as the use of irrigation during rice cultivation, the use of ponds for fish farming and the storage of water in tanks for livestock provide suitable breeding grounds for anthropophy...

    Authors: Oladimeji Oladepo, Grace O Tona, Frederick O Oshiname and Musibau A Titiloye
    Citation: Malaria Journal 2010 9:91
    Content type: Research Published on:

  11. Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. NAPs participate in the assembly and disassembly of nucleosomes thu...

    Authors: Jasmita Gill, Anuj Kumar, Manickam Yogavel, Hassan Belrhali, SK Jain, Melanie Rug, Monica Brown, Alexander G Maier and Amit Sharma
    Citation: Malaria Journal 2010 9:90
    Content type: Research Published on:

  12. Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falc...

    Authors: Michael H Kinzer, Krisin Chand, Hasan Basri, Edith R Lederman, Augustina I Susanti, Iqbal Elyazar, George Taleo, William O Rogers, Michael J Bangs and Jason D Maguire
    Citation: Malaria Journal 2010 9:89
    Content type: Research Published on:

  13. Early diagnosis and treatment of malaria are necessary components in the control of malaria. The gold standard light microscopy technique has high sensitivity, but is a relatively time-consuming procedure espe...

    Authors: Saad El-Din H Hassan, Somia I Okoued, Mahmoud A Mudathir and Elfatih M Malik
    Citation: Malaria Journal 2010 9:88
    Content type: Research Published on:

  14. Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of m...

    Authors: Lyna Zhang, Donald Prather, Jodi Vanden Eng, Sara Crawford, Simon Kariuki, Feiko ter Kuile, Dianne Terlouw, Bernard Nahlen, Altaf A Lal, Laurence Slutsker, Venkatachalam Udhayakumar and Ya Ping Shi
    Citation: Malaria Journal 2010 9:87
    Content type: Research Published on:

  15. In the advent of increasing international collaborative research involving participants drawn from populations with diverse cultural backgrounds, community engagement becomes very critical for the smooth condu...

    Authors: Aceme Nyika, Roma Chilengi, Deus Ishengoma, Sally Mtenga, Mahamadou A Thera, Mahamadou S Sissoko, John Lusingu, Alfred B Tiono, Ogobara Doumbo, Sodiomon B Sirima, Martha Lemnge and Wen L Kilama
    Citation: Malaria Journal 2010 9:86
    Content type: Case study Published on:

  16. Plasmodium berghei ANKA infection in C57Bl/6 mice induces cerebral malaria (CM), which reproduces, to a large extent, the pathological features of human CM. However, experimental CM incidence is variable (50-100%...

    Authors: Yuri C Martins, Guilherme L Werneck, Leonardo J Carvalho, Beatriz PT Silva, Bruno G Andrade, Tadeu M Souza, Diogo O Souza and Cláudio T Daniel-Ribeiro
    Citation: Malaria Journal 2010 9:85
    Content type: Methodology Published on:

  18. The emergence of pyrethroid resistance in Anopheles gambiae has become a serious concern to the future success of malaria control. In Benin, the National Malaria Control Programme has recently planned to scaling ...

    Authors: Anges W Yadouleton, Gil Padonou, Alex Asidi, Nicolas Moiroux, Sahabi Bio-Banganna, Vincent Corbel, Raphael N'guessan, Dina Gbenou, Imorou Yacoubou, Kinde Gazard and Martin C Akogbeto
    Citation: Malaria Journal 2010 9:83
    Content type: Research Published on:

  19. Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias ...

    Authors: Michael T White, Jamie T Griffin, Chris J Drakeley and Azra C Ghani
    Citation: Malaria Journal 2010 9:82
    Content type: Research Published on:

  20. The mechanisms by which malaria up and down-regulates CYP activities are not understood yet. It is also unclear whether CYP activities are modulated during non-lethal malaria infections. This study was underta...

    Authors: Ana Cecilia AX De-Oliveira, Renato S Carvalho, Flavio HM Paixão, Hellen S Tavares, Luciana S Gueiros, Carolina M Siqueira and Francisco JR Paumgartten
    Citation: Malaria Journal 2010 9:81
    Content type: Research Published on:

  21. With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) an...

    Authors: Florence Fouque, Pascal Gaborit, Romuald Carinci, Jean Issaly and Romain Girod
    Citation: Malaria Journal 2010 9:80
    Content type: Research Published on:

  23. Several cases of malaria are frequently recorded during the dry period in Ouagadougou town (Burkina Faso). This has led to the design of a series of studies focusing on both parasitological and entomological i...

    Authors: Florence Fournet, Maud Cussac, Ali Ouari, Pierre-Erwann Meyer, Hyacinthe K Toé, Louis-Clément Gouagna and Roch K Dabiré
    Citation: Malaria Journal 2010 9:78
    Content type: Research Published on:

  24. Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associat...

    Authors: Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J Blackman and Hermann Bujard
    Citation: Malaria Journal 2010 9:77
    Content type: Research Published on:

  25. The Plasmodium falciparum chimeric protein PfCP-2.9 is a promising asexual-stage malaria vaccine evaluated in clinical trials. This chimeric protein consists of two cysteine-rich domains: domain III of the apical...

    Authors: Heng Peng, Yunfei Hu, Aiguo Zhou, Changwen Jin and Weiqing Pan
    Citation: Malaria Journal 2010 9:76
    Content type: Research Published on:

  26. Analysis of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations in Plasmodium vivax wild isolates has been considered to be a valuable molecular approach for mapping resistance to sulphad...

    Authors: Sedigheh Zakeri, Mandana Afsharpad, Faezeh Ghasemi, Ahmad Raeisi, Najibullah Safi, Waqar Butt, Hoda Atta and Navid D Djadid
    Citation: Malaria Journal 2010 9:75
    Content type: Research Published on:

  27. Parasite resistance to the anti-malarial drug chloroquine is common in eastern Sudan. Dynamic within-host changes in the relative abundance of both sensitive and resistant Plasmodium falciparum parasites were exa...

    Authors: Nahla B Gadalla, Salah Eldin Elzaki, Ebtihal Mukhtar, David C Warhurst, Badria El-Sayed and Colin J Sutherland
    Citation: Malaria Journal 2010 9:74
    Content type: Research Published on:

  28. Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falcipar...

    Authors: Shoichi Shimizu, Yoshio Osada, Tamotsu Kanazawa, Yoshiya Tanaka and Meiji Arai
    Citation: Malaria Journal 2010 9:73
    Content type: Research Published on:

  29. Definite diagnosis of malaria relies on microscopy detection of blood stages of parasites in peripheral blood and requires blood sample collection. The nested PCR method has shown to be more sensitive and supe...

    Authors: Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai and Somchai Jongwutiwes
    Citation: Malaria Journal 2010 9:72
    Content type: Methodology Published on:

  30. Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is un...

    Authors: Christophe K Kikankie, Basil D Brooke, Bart GJ Knols, Lizette L Koekemoer, Marit Farenhorst, Richard H Hunt, Matthew B Thomas and Maureen Coetzee
    Citation: Malaria Journal 2010 9:71
    Content type: Research Published on:

  31. The world is facing an increased threat from new and emerging diseases, and there is concern that climate change will expand areas suitable for transmission of vector borne diseases. The likelihood of vivax ma...

    Authors: Steven W Lindsay, David G Hole, Robert A Hutchinson, Shane A Richards and Stephen G Willis
    Citation: Malaria Journal 2010 9:70
    Content type: Research Published on:

  32. A detailed knowledge of the distribution of the main Anopheles malaria vectors in Kenya should guide national vector control strategies. However, contemporary spatial distributions of the locally dominant Anophel...

    Authors: Robi M Okara, Marianne E Sinka, Noboru Minakawa, Charles M Mbogo, Simon I Hay and Robert W Snow
    Citation: Malaria Journal 2010 9:69
    Content type: Research Published on:

  33. The development of Plasmodium falciparum resistance to chloroquine (CQ) has limited its use in many malaria endemic areas of the world. However, despite recent drug policy changes to adopt the more effective arte...

    Authors: Sabelo V Dlamini, Khalid Beshir and Colin J Sutherland
    Citation: Malaria Journal 2010 9:68
    Content type: Review Published on:

  34. Interest in indoor residual spray (IRS) has been rekindled in recent years, as it is increasingly considered to be a key component of integrated malaria management. Regular spraying of each human dwelling beco...

    Authors: Guofa Zhou, Andrew K Githeko, Noboru Minakawa and Guiyun Yan
    Citation: Malaria Journal 2010 9:67
    Content type: Research Published on:

  35. The wide use of gametocytocidal artemisinin-based combination therapy (ACT) lead to a reduction of Plasmodium falciparum transmission in several African endemic settings. An increased impact on malaria burden may...

    Authors: Leonardo Lucantoni, Rakiswendé S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito and Annette Habluetzel
    Citation: Malaria Journal 2010 9:66
    Content type: Research Published on:

  36. Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competiti...

    Authors: Kiattawee Choowongkomon, Sasikrit Theppabutr, Napat Songtawee, Nicholas PJ Day, Nicholas J White, Charles J Woodrow and Mallika Imwong
    Citation: Malaria Journal 2010 9:65
    Content type: Research Published on:

  37. Infection with Plasmodium is the cause of malaria, a disease characterized by a high inflammatory response in the blood. Dendritic cells (DC) participate in both adaptive and innate immune responses, influencing ...

    Authors: Esther Bettiol, Daniel Carapau, Cristina Galan-Rodriguez, Carlos Ocaña-Morgner and Ana Rodriguez
    Citation: Malaria Journal 2010 9:64
    Content type: Research Published on:

  38. Although malaria in pregnancy can cause very significant neonatal morbidity, congenital malaria is a very rare condition in both endemic and non-endemic areas. A case of congenital malaria by Plasmodium vivax, in...

    Authors: Veronica Del Punta, Maurizio Gulletta, Alberto Matteelli, Vania Spinoni, Antonio Regazzoli and Francesco Castelli
    Citation: Malaria Journal 2010 9:63
    Content type: Case report Published on:

  39. High coverage of insecticide-treated bed nets in Asembo and low coverage in Seme, two adjacent communities in western Nyanza Province, Kenya; followed by expanded coverage of bed nets in Seme, as the Kenya nat...

    Authors: M Nabie Bayoh, Derrick K Mathias, Maurice R Odiere, Francis M Mutuku, Luna Kamau, John E Gimnig, John M Vulule, William A Hawley, Mary J Hamel and Edward D Walker
    Citation: Malaria Journal 2010 9:62
    Content type: Research Published on:

  40. New malaria treatment guidelines in Tanzania have led to the large-scale deployment of artemether-lumefantrine (Coartem®), popularly known as ALu or dawa mseto. Very little is known about how people in malaria en...

    Authors: Vinay R Kamat and Daniel J Nyato
    Citation: Malaria Journal 2010 9:61
    Content type: Research Published on:

  42. Accurate information on the geographical distribution of malaria is important for efficient resource allocation. The Lao People's Democratic Republic has experienced a major decline in malaria morbidity and mo...

    Authors: Pernille Jorgensen, Simone Nambanya, Deyer Gopinath, Bouasy Hongvanthong, Kongxay Luangphengsouk, David Bell, Samlane Phompida and Rattanaxay Phetsouvanh
    Citation: Malaria Journal 2010 9:59
    Content type: Research Published on:

  43. In 2005, a nationwide survey estimated that 6.5% of households in Ethiopia owned an insecticide-treated net (ITN), 17% of households had been sprayed with insecticide, and 4% of children under five years of ag...

    Authors: Daddi Jima, Asefaw Getachew, Hana Bilak, Richard W Steketee, Paul M Emerson, Patricia M Graves, Teshome Gebre, Richard Reithinger and Jimee Hwang
    Citation: Malaria Journal 2010 9:58
    Content type: Research Published on:

  44. Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemis...

    Authors: Jianping Song, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng, Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian and Guoqiao Li
    Citation: Malaria Journal 2010 9:57
    Content type: Research Published on:

  45. The use of drug combinations, including non-artemisinin-based and artemisinin-based combination therapy (ACT), is a novel strategy that enhances therapeutic efficacy and delays the emergence of multidrug-resis...

    Authors: Solange Youdom Whegang, Rachida Tahar, Vincent Ngane Foumane, Georges Soula, Henri Gwét, Jean-Christophe Thalabard and Leonardo K Basco
    Citation: Malaria Journal 2010 9:56
    Content type: Research Published on:

  46. Larval mosquito habitats of potential malaria vectors and related species of Anopheles from three provinces (Gyeonggi, Gyeongsangbuk, Chungcheongbuk Provinces) of the Republic of Korea were surveyed in 2007. This...

    Authors: Leopoldo M Rueda, Tracy L Brown, Heung Chul Kim, Sung-Tae Chong, Terry A Klein, Desmond H Foley, Assaf Anyamba, Matthew Smith, Edwin P Pak and Richard C Wilkerson
    Citation: Malaria Journal 2010 9:55
    Content type: Research Published on:

  47. The Tanzanian government recommends women who attend antenatal care (ANC) clinics to accept receiving intermittent preventive treatment against malaria during pregnancy (IPTp) and vouchers for insecticide-trea...

    Authors: Godfrey M Mubyazi, Paul Bloch, Pascal Magnussen, Øystein E Olsen, Jens Byskov, Kristian S Hansen and Ib C Bygbjerg
    Citation: Malaria Journal 2010 9:54
    Content type: Research Published on:

  48. Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of t...

    Authors: Akintunde Sowunmi, Elsie O Adewoye, Grace O Gbotsho, Christian T Happi, Abayomi Sijuade, Onikepe A Folarin, Titilope M Okuboyejo and Obaro S Michael
    Citation: Malaria Journal 2010 9:53
    Content type: Research Published on:

  49. Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004. A study to evaluate efficacies of chlo...

    Authors: Inge Sutanto, Dedeh Endawati, Liem Hui Ling, Ferdinand Laihad, Rianto Setiabudy and J Kevin Baird
    Citation: Malaria Journal 2010 9:52
    Content type: Research Published on:

  50. Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates >95% with good tolerability.

    Authors: Abdunoor M Kabanywanyi, Christian Lengeler, Prudensiana Kasim, Said King'eng'ena, Raymond Schlienger, Nathan Mulure and Blaise Genton
    Citation: Malaria Journal 2010 9:48
    Content type: Research Published on:
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Malaria Journal

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